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D R M A N I S H
RAJPUT
ht t ps://dr manishr ajput .com
Bookan appointment!
IN T R O D U C T IO N
Dr
. Manish Rajput is an I
nterventional
Radiologist & Team Lead, Team I
R
Jaipur
. They are the biggest team of
I
nterventional Radiologists. They are
trained from Tata Memorial Center
,
Mumbai, I
ndia. They have worked in so
many government and corporate
hospitals across the country.
Medical school (MBBS):2005-2011: -People’s
Medical College, Bhopal(MP)
DNB (Radio diagnosis):
- Apollo hospital,
Hyderabad(Telangana)
FVIR (PDCC):- Tata Memorial Centre,
Mumbai(Maharashtra)
Senior Resident: Hinduja Hospital Mumbai, SMS
Hospital Jaipur
Past Visiting Doctor:Leelavati Hospital Mumbai,
Breach Candy Hospital Mumbai, Wockhardt
Hospital Mumbai, Hinduja Hospital Mumbai
Ex Assitant Professor:JNU Medical College, Jaipur
Currently Working as Senior Consultant
Interventional Radiologist in various corporate
hospitals of Rajasthan based in Jaipur
HIS
EDUCATION
S T R E N G T H S
Ilead the biggest I
R team in the state.
Vast portfolio for I
R services.
All the team members are from Tata
Memorial Hospital, Mumbai.
Extensive experience in performing and
interpreting basic Radio-Diagnosis.
Gained experience in performing
I
nterventional Radiologic procedures.
Ipossess oratory skill by speaking at
numerous industry events.
Ability to teach complex concepts in a basic
manner
.
Varicose Veins Prostate Artery Embolization PRG
Biopsy and
fNAC
Angioplasty & Venoplasty PCN & DJ Stenting
O
U
R
S
E
R
V
I
C
E
S
+91 7729021111
dr.manish@infinityintervention.com
O-5-A, Adinath Marg, Near Surya
Hospital, C Scheme, Ashok Nagar,
Jaipur, Rajasthan 302001
C ON TA C T
US!

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Good Automated Laboratory Practices (GALP) Standards, Compliance, and Impleme... by Dr. Smita Kumbhar, has 36 slides with 263 views.Good Automated Laboratory Practices (GALP) refers to a structured framework designed to ensure the reliability, accuracy, and integrity of data generated by automated laboratory systems. These practices encompass standard operating procedures (SOPs), regulatory compliance, software validation, and personnel training to maintain consistency in laboratory operations. GALP is essential for laboratories that rely on automation to process high volumes of data while ensuring regulatory adherence, particularly in pharmaceutical, biotechnology, and clinical research environments. Principles of GALP The fundamental principles of GALP include: 1. Data Integrity: Ensuring accurate, reliable, and tamper-proof data recording and analysis. 2. Regulatory Compliance: Adhering to national and international standards such as ISO, 21 CFR Part 11, and QCI guidelines. 3. Standardized Processes: Implementing well-defined SOPs to guide laboratory operations. 4. System Validation: Regularly verifying automated instruments and software for functionality and compliance. 5. Personnel Training: Ensuring that laboratory staff are adequately trained to operate automated systems efficiently and accurately. 6. Risk Management: Identifying and mitigating potential risks in automated workflows. 7. Continuous Improvement: Periodic reviews and updates to laboratory practices to incorporate technological advancements. GALP Requirements To implement GALP, laboratories must adhere to certain requirements: 1. Standardized Documentation: Maintaining comprehensive records of laboratory procedures and automation processes. 2. Software and Instrument Validation: Ensuring that all automated systems function as intended and comply with regulatory requirements. 3. Data Security Measures: Implementing encryption, access control, and audit trails for secure data management. 4. Regulatory Compliance: Aligning with relevant regulations such as 21 CFR Part 11, ISO standards, and QCI guidelines. 5. Personnel Competency: Conducting periodic training and assessments for laboratory staff. 6. Audit Readiness: Preparing for internal and external inspections by maintaining up-to-date documentation. SOPs of GALP Standard Operating Procedures (SOPs) form the backbone of GALP. These SOPs cover: 1. Instrument Calibration: Regular calibration and validation of automated instruments. 2. Data Entry and Management: Guidelines on recording, storing, and retrieving data in compliance with regulatory standards. 3. Sample Handling: Ensuring standardized procedures for sample collection, processing, and storage. 4. Software Usage and Maintenance: Guidelines on software validation, updates, and troubleshooting. 5. Audit Trail Management: Recording and reviewing all modifications made to electronic data. 6. Corrective and Preventive Actions (CAPA): Addressing non-compliance and implementing necessary improvements. Training Documentation A key aspect of GALP is personnel training, which includes: 1. Training Plans
Good Automated Laboratory Practices (GALP) Standards, Compliance, and Impleme...Good Automated Laboratory Practices (GALP) Standards, Compliance, and Impleme...
Good Automated Laboratory Practices (GALP) Standards, Compliance, and Impleme...
Dr. Smita Kumbhar
36 slides263 views
Detailed Overview of the Drugs and Cosmetics Act, 1940 & Rules by Dr.Navaneethakrishnan S, has 23 slides with 242 views.This presentation provides a comprehensive overview of the Drugs and Cosmetics Act, 1940, and its associated rules from 1945. It covers the objectives of the Act, its significance in regulating the import, manufacture, distribution, and sale of drugs and cosmetics in India. Key definitions such as drugs, cosmetics, misbranded, adulterated, and spurious products are explained in detail. Additionally, it highlights the legal definitions and important schedules to the Act, ensuring clarity on regulatory standards. Essential roles such as Drug Inspector and Government Analyst are also discussed. This presentation is useful for pharmacy students, regulatory professionals, and individuals interested in pharmaceutical law.
Detailed Overview of the Drugs and Cosmetics Act, 1940 & RulesDetailed Overview of the Drugs and Cosmetics Act, 1940 & Rules
Detailed Overview of the Drugs and Cosmetics Act, 1940 & Rules
Dr.Navaneethakrishnan S
23 slides242 views
Let's Talk About It: Ovarian Cancer (Making Meaning after a Cancer Diagnosis) by RheannaRandazzo, has 19 slides with 313 views.Making meaning from hardship is a complex conversation. Many cancer survivors feel the delicate balance between making meaning and the internalized or external pressure that often follows a cancer diagnosis. Questions such as “What now?” are common when treatment ends. Well-meaning friends and family may subtly (or not so subtly) expect us to behave or view the world differently. If figuring out who you are now feels puzzling, join us on Wednesday, December 11th. Together, we will discuss how changes in your identity and perspective are a valid and essential part of this journey. Research has shown us how making meaning after hardship facilitates adjustment and well-being.
Let's Talk About It: Ovarian Cancer (Making Meaning after a Cancer Diagnosis)Let's Talk About It: Ovarian Cancer (Making Meaning after a Cancer Diagnosis)
Let's Talk About It: Ovarian Cancer (Making Meaning after a Cancer Diagnosis)
RheannaRandazzo
19 slides313 views
urine formation.pptx kidney urine formation by Pooja Rani, has 27 slides with 126 views.urine formation
urine formation.pptx kidney urine formationurine formation.pptx kidney urine formation
urine formation.pptx kidney urine formation
Pooja Rani
27 slides126 views
Time-Limited Innovation for CLL Control: Changing the Treatment Story With Ev... by PVI, PeerView Institute for Medical Education, has 40 slides with 18 views.Chair, Nitin Jain, MD, discusses chronic lymphocytic leukemia in this CME/AAPA activity titled “Time-Limited Innovation for CLL Control: Changing the Treatment Story With Evidence and Emerging Consensus on 1L BTKi -BCL2i Combinations.” For the full presentation, downloadable Practice Aid, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/4gi5jVw. CME/AAPA credit will be available until April 3, 2026.
Time-Limited Innovation for CLL Control: Changing the Treatment Story With Ev...Time-Limited Innovation for CLL Control: Changing the Treatment Story With Ev...
Time-Limited Innovation for CLL Control: Changing the Treatment Story With Ev...
PVI, PeerView Institute for Medical Education
40 slides18 views
PEPTIC ULCER DISEASE (PUD) , H PYLORI AND GERD TREATMENT BY DR .ANKUSH GOYAL ... by Dr Ankush goyal, has 43 slides with 37 views.Comprehensive Management of Peptic Ulcer Disease and GERD I. Introduction Peptic Ulcer Disease (PUD) and Gastroesophageal Reflux Disease (GERD) are distinct yet overlapping disorders of the gastrointestinal system, marked by significant morbidity worldwide. These conditions illustrate the consequence of a disturbed harmony between offensive gastric secretions and the protective barriers of the mucosa. From ancient remedies to modern-day proton pump inhibitors and eradication therapies, the treatment approaches to these disorders represent a triumph of translational medicine. While PUD typically involves mucosal erosion in the stomach or proximal duodenum due to Helicobacter pylori infection or NSAID use, GERD arises from the reflux of gastric contents into the esophagus due to incompetent lower esophageal sphincter tone. Both conditions necessitate a thorough understanding of their etiopathogenesis for rational therapy and long-term management. This document explores the latest, evidence-based treatment paradigms, structured with clarity and clinical relevance. --- II. Peptic Ulcer Disease (PUD) Definition and Epidemiology Peptic ulcers are breaks in the mucosal lining of the stomach or duodenum that penetrate the muscularis mucosa. Gastric ulcers typically occur on the lesser curvature of the stomach, while duodenal ulcers are found in the first part of the duodenum. Globally, the prevalence of PUD has declined, largely due to H. pylori eradication, yet NSAID-related ulcers persist, especially among the elderly. Etiology and Risk Factors Helicobacter pylori infection – Present in ~90% of duodenal and 70% of gastric ulcers. NSAIDs – Inhibit prostaglandin synthesis, compromising mucosal defense. Smoking – Impairs mucosal healing. Stress (critical illness) – Leads to stress ulcers. Zollinger-Ellison Syndrome – Gastrinoma with excess acid secretion. Corticosteroids, alcohol, and genetic predisposition are other contributors. Pathophysiology The balance between aggressive factors (acid, pepsin, H. pylori, NSAIDs) and defensive mechanisms (mucus, bicarbonate, blood flow, prostaglandins) determines mucosal integrity. H. pylori causes chronic inflammation and epithelial damage. NSAIDs decrease prostaglandins, reducing mucosal blood flow and bicarbonate production. --- III. Clinical Features of Peptic Ulcer Epigastric pain: Most common symptom; burning or gnawing in nature. Duodenal ulcers: Pain relieved by food, occurs 2–3 hours after meals. Gastric ulcers: Pain worsens with food intake. Nausea, bloating, early satiety Complications: Bleeding: Hematemesis, melena. Perforation: Sudden severe abdominal pain. Gastric outlet obstruction Penetration into adjacent organs (e.g., pancreas) --- IV. Diagnosis of Peptic Ulcer Endoscopy: Gold standard for diagnosis and biopsy to rule out malignancy. Rapid urease test, histology, urea breath test, stool antigen – for H. pylori. Serologic testing (less preferred). Barium study
PEPTIC ULCER DISEASE (PUD) , H PYLORI AND GERD TREATMENT BY DR .ANKUSH GOYAL ...PEPTIC ULCER DISEASE (PUD) , H PYLORI AND GERD TREATMENT BY DR .ANKUSH GOYAL ...
PEPTIC ULCER DISEASE (PUD) , H PYLORI AND GERD TREATMENT BY DR .ANKUSH GOYAL ...
Dr Ankush goyal
43 slides37 views
Autocoids mcq.ankush goyal gmc patiala punjab by Dr Ankush goyal, has 54 slides with 227 views.Lipid Autocoids: A Comprehensive Overview Introduction Lipid autocoids, also known as eicosanoids and related lipid mediators, are bioactive molecules derived from polyunsaturated fatty acids (PUFAs). These molecules play crucial roles in inflammation, immunity, hemostasis, cardiovascular function, and various physiological and pathological processes. Unlike classical hormones, lipid autocoids act locally, exerting their effects at or near their site of synthesis. This document provides an in-depth analysis of lipid autocoids, covering their biosynthesis, classification, physiological roles, and clinical significance. Classification of Lipid Autocoids Lipid autocoids are broadly classified into the following categories: 1. Eicosanoids (Derived from Arachidonic Acid) Prostaglandins (PGs) Thromboxanes (TXs) Leukotrienes (LTs) Lipoxins (LXs) 2. Specialized Pro-resolving Mediators (SPMs) Resolvins Protectins Maresins 3. Endocannabinoids Anandamide (AEA) 2-Arachidonoylglycerol (2-AG) 4. Platelet-Activating Factor (PAF) 5. Sphingolipid-Derived Mediators Sphingosine-1-Phosphate (S1P) Ceramides Biosynthesis of Lipid Autocoids Lipid autocoids are derived from membrane phospholipids through enzymatic pathways: 1. Phospholipase A2 (PLA2) Activation: PLA2 catalyzes the release of arachidonic acid (AA) from membrane phospholipids. 2. Cyclooxygenase (COX) Pathway: Converts AA into prostaglandins and thromboxanes. COX-1: Constitutive enzyme (housekeeping functions). COX-2: Inducible enzyme (inflammation and pain response). 3. Lipoxygenase (LOX) Pathway: Converts AA into leukotrienes and lipoxins. 5-LOX: Leads to leukotrienes (inflammation, bronchoconstriction). 12-LOX & 15-LOX: Lead to lipoxins (anti-inflammatory action). 4. Cytochrome P450 (CYP) Pathway: Converts AA into epoxyeicosatrienoic acids (EETs), which regulate vascular tone. 5. Endocannabinoid Biosynthesis: Derived from membrane phospholipids via enzymatic reactions. Degraded by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Physiological Roles of Lipid Autocoids 1. Inflammation and Immune Response Prostaglandins (e.g., PGE2) modulate fever and pain. Leukotrienes mediate allergic responses and asthma. Lipoxins and resolvins promote resolution of inflammation. 2. Cardiovascular System Thromboxanes (TXA2) induce platelet aggregation and vasoconstriction. Prostacyclin (PGI2) inhibits platelet aggregation and promotes vasodilation. EETs regulate blood pressure and vascular homeostasis. 3. Pulmonary Function Leukotrienes (LTC4, LTD4, LTE4) are potent bronchoconstrictors. PGE2 has bronchodilatory effects. 4. Renal Function Prostaglandins regulate glomerular filtration rate and sodium excretion. EETs contribute to natriuresis. 5. Neurotransmission and Pain Endocannabinoids modulate pain perception and neuroprotection. Prostaglandins contribute to central pain sensitization. 6. Reproductive System P
Autocoids mcq.ankush goyal gmc patiala punjabAutocoids mcq.ankush goyal gmc patiala punjab
Autocoids mcq.ankush goyal gmc patiala punjab
Dr Ankush goyal
54 slides227 views
Good Automated Laboratory Practices (GALP) Standards, Compliance, and Impleme... by Dr. Smita Kumbhar, has 36 slides with 263 views.Good Automated Laboratory Practices (GALP) refers to a structured framework designed to ensure the reliability, accuracy, and integrity of data generated by automated laboratory systems. These practices encompass standard operating procedures (SOPs), regulatory compliance, software validation, and personnel training to maintain consistency in laboratory operations. GALP is essential for laboratories that rely on automation to process high volumes of data while ensuring regulatory adherence, particularly in pharmaceutical, biotechnology, and clinical research environments. Principles of GALP The fundamental principles of GALP include: 1. Data Integrity: Ensuring accurate, reliable, and tamper-proof data recording and analysis. 2. Regulatory Compliance: Adhering to national and international standards such as ISO, 21 CFR Part 11, and QCI guidelines. 3. Standardized Processes: Implementing well-defined SOPs to guide laboratory operations. 4. System Validation: Regularly verifying automated instruments and software for functionality and compliance. 5. Personnel Training: Ensuring that laboratory staff are adequately trained to operate automated systems efficiently and accurately. 6. Risk Management: Identifying and mitigating potential risks in automated workflows. 7. Continuous Improvement: Periodic reviews and updates to laboratory practices to incorporate technological advancements. GALP Requirements To implement GALP, laboratories must adhere to certain requirements: 1. Standardized Documentation: Maintaining comprehensive records of laboratory procedures and automation processes. 2. Software and Instrument Validation: Ensuring that all automated systems function as intended and comply with regulatory requirements. 3. Data Security Measures: Implementing encryption, access control, and audit trails for secure data management. 4. Regulatory Compliance: Aligning with relevant regulations such as 21 CFR Part 11, ISO standards, and QCI guidelines. 5. Personnel Competency: Conducting periodic training and assessments for laboratory staff. 6. Audit Readiness: Preparing for internal and external inspections by maintaining up-to-date documentation. SOPs of GALP Standard Operating Procedures (SOPs) form the backbone of GALP. These SOPs cover: 1. Instrument Calibration: Regular calibration and validation of automated instruments. 2. Data Entry and Management: Guidelines on recording, storing, and retrieving data in compliance with regulatory standards. 3. Sample Handling: Ensuring standardized procedures for sample collection, processing, and storage. 4. Software Usage and Maintenance: Guidelines on software validation, updates, and troubleshooting. 5. Audit Trail Management: Recording and reviewing all modifications made to electronic data. 6. Corrective and Preventive Actions (CAPA): Addressing non-compliance and implementing necessary improvements. Training Documentation A key aspect of GALP is personnel training, which includes: 1. Training Plans
Good Automated Laboratory Practices (GALP) Standards, Compliance, and Impleme...Good Automated Laboratory Practices (GALP) Standards, Compliance, and Impleme...
Good Automated Laboratory Practices (GALP) Standards, Compliance, and Impleme...
Dr. Smita Kumbhar
36 slides263 views

DR MANISH-2.pdf laser proctology piles and fistula

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  • 2. IN T R O D U C T IO N Dr . Manish Rajput is an I nterventional Radiologist & Team Lead, Team I R Jaipur . They are the biggest team of I nterventional Radiologists. They are trained from Tata Memorial Center , Mumbai, I ndia. They have worked in so many government and corporate hospitals across the country.
  • 3. Medical school (MBBS):2005-2011: -People’s Medical College, Bhopal(MP) DNB (Radio diagnosis): - Apollo hospital, Hyderabad(Telangana) FVIR (PDCC):- Tata Memorial Centre, Mumbai(Maharashtra) Senior Resident: Hinduja Hospital Mumbai, SMS Hospital Jaipur Past Visiting Doctor:Leelavati Hospital Mumbai, Breach Candy Hospital Mumbai, Wockhardt Hospital Mumbai, Hinduja Hospital Mumbai Ex Assitant Professor:JNU Medical College, Jaipur Currently Working as Senior Consultant Interventional Radiologist in various corporate hospitals of Rajasthan based in Jaipur HIS EDUCATION
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